Thanks to a paramount clinical investigation method, i.e., Quantum Biophysical Semeiotics, I discovered a lot of constitutions and related inherited real risks, conditio sine qua non of most common and severe human diseases, including type 2 diabetes, and Cancer, both solid and liquid. Due to such as precious clinical tool, physicians now-a-days are able to bedside evaluate the majority of functions of different biological sistems, as beta-cells of Langherans's isles. As a consequence, in presence of genetic alterations, secondary to mutation of one or more genes, physicians can assess the dysfunctions, which parallel the former, genetic modifications, bedside evaluating the structure and fluctations of related microcirculatory bed, according to Angiobiopathy. In fact, all gene mutations bring about modification of parechymal anathomy and functions, as I illustrated in www.semeioticabiofisica.it From the above brief remarks, utilizing a simple stethoscope, doctor can recognize since birth in quantitative way , e.g., individuals predisposed to diabetes and/or maignancy in well-defined biological system..