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Hi Anton - thanks for the feedback. Unfortunately, the journal websites with the performance issues run on the TOPAZ platform. Only www.plos.org runs on Drupal. After some patches in the last two weeks, the TOPAZ websites serve almost all content from ehcache which gzips all objects in its cache.
We'll have to take a look at Varnish. We currently use a Squid proxy with our Apache servers.
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