This seems like a valuable concept. Although prospective IACUC approval is intended to mitigate against inappropriate use of experimental animals, perhaps a comprehensive registry (daunting even to consider!) could add another layer of accountability to the process. If purchasers or breeders of animals were responsible for registering them and reporting ultimate disposition / fate, we might have a database of experimental data (whether or not the results were deemed publishable), as well as some means to monitor the ethical use of these animals.

Would you consider each and every animal purchased for experimental use to be "enrolled" in a trial? How would you monitor animals bred in-house? If such a comprehensive enrollment isn't used, how can you ensure that all experiments are included in the database?